The Principe Pio Hotel can be found in the heart of the city. The Plaza de Espana and Gran Via are both within moments of the hotel. Casa de Campo and the Madrid Amusement Park are also within easy reach of this hotel in Madrid. The hotel is located within walking distance of 2 metro stations. The metro, along with rental cars and taxis, offers easy access to Madrid attractions, as well as to the airport located a short driving distance from the hotel.

All of the guestrooms at the Principe Pio Hotel include a classic décor. There are 155 rooms on offer, all of which include direct dial phones, safes, air conditioning, desks, and more. Private bathrooms offer showers and tubs, as well as bidets.

Guests will discover that the area offers numerous bars, restaurants, and shops. There is a 24 hour concierge service on offer. The hotel also has an international restaurant and a relaxing onsite bar.